Scleroderma, or systemic sclerosis, is a persistent connective tissue ailment often named one of the immune system rheumatic infections. Scleroderma is not infectious, carcinogenic or dangerous. Any chronic ailment is a very serious problem. The manifestations of scleroderma differ significantly for every individual, and the impacts of scleroderma can run from moderate to life debilitating. It will rely on upon the parts of the body, which are affected, and the degree to which they are affected.