Most instances of systemic scleroderma are occasional, which implies they happen in individuals with no history of the condition in their family. In any case, a few people with systemic scleroderma have close relatives with other immune system problems. A small part of incidences of systemic scleroderma has been accounted for to keep running in families. However, the condition does not have a clear pattern of inheritance. Numerous hereditary and natural components likely have an influence in deciding the danger of building up this condition. Subsequently, acquiring a hereditary variety connected with systemic scleroderma does not imply that a man will have this condition.